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What disease causes leg swelling? Leg swelling generally occurs because of an abnormal accumulation of fluid in the tissues of the lower extremity. The medical term for leg swelling from excessive fluid in the tissues is peripheral edema. Persisting indentation of a swollen leg after pressure from a finger is known as pitting edema. Why are my feet swollen in the morning? Sometimes swelling can indicate a problem such as heart, liver, or kidney disease. Ankles that swell in the evening could be a sign of retaining salt and water because of right-sided heart failure. Gravity causes fluid to accumulate more in the feet and ankles, but fluid can also accumulate in the abdomen and chest.
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