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How long do Effexor side effects last? It usually takes 4 to 6 weeks for venlafaxine to work. Side effects such as feeling sick, headaches, sweating, and dry mouth are common. They are usually mild and go away after a couple of weeks. What antidepressants help with sleep? The sedating antidepressants most commonly used to help with sleep include Trazodone (Desyrel), Amitriptyline (Elavil), and Doxepin (Sinequan). It should be noted that when these medications are used for sleeping and pain relieving properties, it is in much lower doses than when used in the treatment of depression. How does clozapine work in the body? Clozapine is an anti-psychotic medication that works by blocking receptors in the brain for several neurotransmitters (chemicals that nerves use to communicate with each other) including dopamine type 4 receptors, serotonin type 2 receptors, norepinephrine receptors, acetylcholine receptors, and histamine receptors.
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